Histone H1 Phosphorylation in Breast Cancer
نویسندگان
چکیده
منابع مشابه
Histone H1 Phosphorylation in Breast Cancer
Breast cancer is the second leading cause of cancer-related deaths in women. The need for new clinical biomarkers in breast cancer is necessary to further predict prognosis and therapeutic response. In this article, the LC-MS histone H1 phosphorylation profiles were established for three distinct breast cancer cell lines. The results show that the extent of H1 phosphorylation can distinguish be...
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It is shown here that one can induce prematurely condensed chromosomes (PCCs) in G1-phase human (HeLa) and mouse (FT210) cells by treating them with the protein phosphatase inhibitor calyculin A. However, histone H1 is not phosphorylated in these G1-PCCs. It has previously been proposed that histone H1 phosphorylation is responsible for mitotic chromosome condensation, but our results suggest t...
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ژورنال
عنوان ژورنال: Journal of Proteome Research
سال: 2014
ISSN: 1535-3893,1535-3907
DOI: 10.1021/pr401248f